Focus on Traumatic Brain Injury Research

Focus on Traumatic Brain Injury Research

Photo of brain MRI scan. Focus On Traumatic Brain Injury banner image.

NINDS Program Description

Traumatic brain injury (TBI) occurs when external physical forces cause damage to the brain, whether from impact, penetrating objects, blast waves or rapid movement of the brain within the skull.  TBI severity has been classified as mild, moderate or severe based primarily on the Glasgow Coma Scale in combination with an assessment of periods of loss/alterations of consciousness and imaging scans of the brain.  The classification of mild TBI also includes concussion, commonly defined as a transient alteration of brain function after exposure to external physical forces. While short-term TBI can be life threatening in some cases, TBI also can have long-term sequelae including cognitive dysfunction, pain, sleep disorders and physical disability collectively known as the post-concussion syndrome (PCS). PCS results when various symptoms of TBI last weeks, months or more than a year following the TBI incident.  Chronic traumatic encephalopathy (CTE) is a delayed neurodegenerative disorder that was initially identified in the postmortem brains of subjects with a history of repetitive brain injuries. Diagnostic criteria for CTE and the associated Traumatic Encephalopathy Syndrome (TES) are being investigated further.

The TBI program at NINDS provides support and funds to extramural researchers studying basic, clinical and translational TBI research. NINDS-funded research includes studies to understand mechanisms of TBI and its sequelae, preclinical and clinical studies for diagnosis, prognosis, potential therapeutics, and other aspects of TBI.

Additional general information about TBI can be found at the NINDS TBI Hope Through Research website.

 

 

 

Estimates of Funding for Various Research, Condition, and Disease Categories

Research/Disease Areas* FY 2013
(Actual)
FY 2014
(Actual)
FY 2015
(Actual)
FY 2016
(Actual)
FY 2017
(Actual)
FY 2018
(Actual)
FY 2019
(Actual)
FY 2020
(Actual)
FY 2021 
(Estimated)
FY 2022 
(Estimated)
Injury - Traumatic Brain Injury $88 $87 $93 $105 $116 $133 $134 $179 $184 $192

*Dollars in millions and rounded

Resources and Tools

NINDS strongly encourages researchers who receive funding from the Institute to use these common data elements (CDEs) in their clinical research.

The FITBIR Informatics System is a database developed by the Department of Defense and National Institutes of Health to share data, associated tools and methodologies. NINDS has specific FITBIR requirements for larger Clinical Research studies.

FITBIR Data Sharing Policy (pdf, 542 kb)

InTBIR is a cooperative international effort to coordinate clinical research activities, increase data sharing, and leverage global research opportunities.