The mission of the NINDS Division of Clinical Research is to provide oversight for clinical trials to test the safety and efficacy of innovative treatments of neurological disorders and stroke, epidemiological studies of natural history, biomarker studies, and studies designed to elucidate the causes of neurological disorders. DCR also develops new clinical science initiatives, ensures the proper level of patient safety monitoring, maintains the scientific integrity of clinical trials, and provides expertise in statistics and clinical trial design to the Institute and to clinical investigators.
Investigators are encouraged to contact the program director who is responsible for the disease of interest. View a list of NINDS program directors by category.
View information related to translational research.
Clinical Trial Definition
Clinical Trial FORMS-E (use on or before May 24, 2020)
Clinical Trial FORMS-F (use on or after May 25, 2020)
Certificates of Confidentiality
Single IRB Policy
Guidelines for monitoring data and safety from ongoing clinical trials. Responsibilities, membership, and reporting are included.
Learn more about Data & Safety Monitoring Board (DSMB)
Information for NINDS-awardees in the use of CDEs in clinical trials and exploratory trials.
Learn more about CDE's
|Within the Division of Clinical Research, the office of Global Health and Health Disparities (OGHHD) leads the coordination and development of programs and initiatives that foster global research and research on health disparities in neurological disorders and stroke. Richard T. Benson, M.D., Ph.D.|
|Early Phase Pain Investigation Clinical Network (EPPIC-Net)
Early phase clinical trials of highly meritorious, non-addictive pain therapies in well-characterized patient cohorts with pain conditions of high unmet need.
Contact: Barbara I. Karp, M.D.
|Stroke Trials Network (NIH StrokeNet)
Phase III clinical trials as well as early phase trials and biomarker studies preparatory to phase III clinical trials in stroke prevention, treatment and recovery.
Contact: Scott Janis, Ph.D.
Early phase clinical trials and biomarker studies preparatory to phase III clinical trials in neurological disorders.
Contact: Codrin Lungu, M.D.
|SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network)
Clinical trials in neurologic, heart, lung, blood, and traumatic emergencies.
Contact: Jeremy Brown, M.D.
|Neurological Emergencies Treatment Trials (NETT) Network
Phase III trials of acute injuries and illnesses affecting the brain, spinal cord and peripheral nervous system. *For new applications requesting network support of emergency care trials see SIREN (above).
Contact: Robin Conwit, M.D.