Animal Models

Animal Models

The Knockout Mouse Project (KOMP) and the Knockout Mouse Phenotyping Program (KOMP2)

Knockout mice are a powerful tool to study gene function and nervous system physiology, given the genomic similarity between mice and humans. The trans-NIH funded Knockout Mouse Project (KOMP) was launched in 2006 to support the generation of a comprehensive resource in mouse Embryonic Stem (ES) cells with null deletions of all protein-coding genes in the mouse genome, in the standard C57BL/6 mouse strain. These resources are publicly available from the MMRC at UC Davies. To speed up efforts to generate knockout mice from those ES cells and to characterize gene function rigorously and systematically, the NIH Common Fund Knockout Mouse Phenotyping Program (KOMP2) was created in 2011 to replace KOMP. KOMP2 is part of the International Mouse Phenotyping Consortium (IMPC). All data and mouse lines from KOMP2/IMPC knockout mice projects are openly available to researchers around the world.

The International Mouse Phenotyping Consortium (IMPC)

The International Mouse Phenotyping Consortium (IMPC) is an international confederation across 15 countries and consisting of 21 research institutions, including the NIH Common Fund KOMP2 program, working to identify the function of every protein-coding gene in the mouse genome. The mission of  the IMPC is to generate and characterize mice with knockout of the ~21,000 known and predicted mouse genes and to create a comprehensive catalogue of gene function that is freely available to researchers. IMPC scientists adhere to uniform and standardized protocols for data collection, data reporting, and phenotyping across a broad range of biological systems to discover gene function. Data and mice generated by the IMPC is distributed freely to the scientific community on the IMPC website.

Alliance of Genome Resources

The Alliance of Genome Resources (the Alliance) was established in 2016 and is a consortium of six Model Organism Databases (MODs) and the Gene Ontology Consortium (GOC). The mission of the Alliance is to develop and maintain genome information resources for the scientific community that would facilitate the use of diverse model organisms in scientific research. The Alliance includes six-National Human Genome Research Institute (NHGRI) and one National Heart, Lung, and Blood Institute (NHLBI)-funded MOD/data resources. The six NHGRI-funded MODs/data resources are: Mouse Genome Database, WormBase, Zebrafish Information Network, Saccharomyces Genome Database, Flybase, and the Gene Ontology Consortium. The NHLBI-funded MOD is the Rat Genome Database. The Alliance was established to provide a common infrastructure and searchable software platform for all the NIH-supported MODs/data resources. The Alliance is supported by NIH NHGRI and NHLBI U24HG010859

Webpage(s):
Home | Alliance of Genome Resources (alliancegenome.org)
The Alliance of Genome Resources (Alliance) Consortium
MGI-Mouse Genome Informatics-The international database resource for the laboratory mouse (jax.org)
WormBase : Nematode Information Resource
ZFIN The Zebrafish Information Network
Saccharomyces Genome Database | SGD (yeastgenome.org)
FlyBase Homepage
Gene Ontology Resource
Rat Genome Database (mcw.edu)